https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48048 Wed 13 Mar 2024 14:19:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22109 Wed 11 Apr 2018 16:41:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29013 P < 2 × 10⁻¹⁶). Further, the gene set analyses revealed several miRNAs regulating schizophrenia risk genes, with the strongest enrichment for targets of miR-9-5p (P = .0056 for enrichment among the top 1% most-associated single-nucleotide polymorphisms, corrected for multiple testing). It is further of note that MIR9-2 is located in a genomic region showing strong evidence for association with schizophrenia (P = 7.1 × 10⁻⁸). The second and third strongest gene set signals were seen for the targets of miR-485-5p and miR-137, respectively. Conclusions and Relevance: This study provides evidence for a role of miR-9-5p in the etiology of schizophrenia. Its implication is of particular interest as the functions of this neurodevelopmental miRNA tie in with established disease biology: it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulates dopamine D₂ receptor density.]]> Wed 11 Apr 2018 15:28:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25334 Wed 11 Apr 2018 15:03:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16812 Wed 11 Apr 2018 12:55:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25795 Wed 11 Apr 2018 12:09:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15110 Wed 11 Apr 2018 11:57:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22783 Wed 11 Apr 2018 11:21:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41686 Wed 10 Aug 2022 15:08:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50345 Wed 06 Mar 2024 14:26:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33146 Poaceae family of grasses, namely; maize (Zea mays L.), wheat (Triticum aestivum L.) and rice (Oryza sativa L.). It is, therefore, of significant concern that all three of these Poaceae grass species are susceptible to a range of abiotic stresses, including drought and salt stress. Highly conserved among monocotyledonous and dicotyledonous plant species, microRNAs (miRNAs) are now well-established master regulators of gene expression, influencing all aspects of plant development, mediating defense responses against pathogens and adaptation to environmental stress. Here we investigate the variation in the abundance profiles of six known abiotic stress-responsive miRNAs, following exposure to salt and drought stress across these three key Poaceae grass crop species as well as to compare these profiles to those obtained from the well-established genetic model plant species, Arabidopsis thaliana (L.) Heynh. Additionally, we outline the variables that are the most likely primary contributors to instances of differential miRNA abundance across the assessed species following drought or salt stress exposure, specifically; (1) identifying variations in the experimental conditions and/or methodology used to assess miRNA abundance, and; (2) the distribution of regulatory transcription factor binding sites within the putative promoter region of a MICRORNA (MIR) gene that encodes the highly conserved, stress-responsive miRNA. We also discuss the emerging role that non-conserved, species-specific miRNAs play in mediating a plant’s response to drought or salt stress.]]> Thu 21 Oct 2021 12:52:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35744 Thu 14 Nov 2019 16:52:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49088 Thu 04 May 2023 13:43:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33586 Thu 03 Feb 2022 12:21:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33259 Thu 03 Feb 2022 12:21:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36721 Thu 03 Feb 2022 12:20:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30084 Thu 03 Feb 2022 12:18:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8212 Sat 24 Mar 2018 08:36:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16016 Sat 24 Mar 2018 08:19:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16891 Sat 24 Mar 2018 08:00:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19725 P<0.05), miR-103 (P<0.01), and miR-107 (P<0.05) expression, a decrease in IR (P<0.05), phopsho- Akt (P<0.01), and phospho-FoxO1 (P<0.01) abundance, and a paradoxical decrease in 11ßHSD1 (P<0.05), PEPCK-C (P<0.01), and PEPCK-M (P<0.05) expression in lambs. These changes were ablated by a period of moderate dietary restriction imposed during the periconceptional period. Maternal dietary restriction alone also resulted in decreased abundance of a separate subset of hepatic insulin-signaling molecules, namely, IRS1 (P<0.05), PDK1 (P<0.01), phospho-PDK1 (P<0.05), and aPKCζ (P<0.05) and in decreased PEPCK-C (P<0.01) and G6Pase (P<0.01) expression in the lamb. Our findings highlight the sensitivity of the epigenome to maternal nutrition around conception and the need for dietary interventions that maximize metabolic benefits and minimize metabolic costs for the next generation.-Nicholas, L. M., Rattanatray, L., MacLaughlin, S. M., Ozanne, S. E., Kleemann, D. O.,Walker, S. K., Morrison, J. L., Zhang, S., Muhlhausler, B. S., Martin-Gronert, M. S., McMillen, I. C. Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring.]]> Sat 24 Mar 2018 07:53:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29820 Sat 24 Mar 2018 07:40:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22118 Sat 24 Mar 2018 07:13:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20638 Mon 19 Aug 2024 09:01:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41301 Mon 01 Aug 2022 12:16:33 AEST ]]>